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      Ionomycin

      更新時間:2022-01-29

      簡要描述:

      Ionomycin is a membrane permeable calcium ionophore produced by the bacterium Streptomyces conglobatus.This ionophore facilitates the transfer of calcium ions (Ca2+) into and out of cells [1]. Iono……

      型號:廠商性質(zhì):代理商瀏覽量:886

      Calcium ionophore - NFAT Activator

      Ionomycin is a membrane permeable calcium ionophore produced by the bacterium Streptomyces conglobatus.

      This ionophore facilitates the transfer of calcium ions (Ca2+) into and out of cells [1]. Ionomycin can be used to increase intracellular calcium levels triggering cell death through apoptosis and autophagy [1].

      Ionomycin is commonly used in conjunction with phorbol myristate acetate (PMA) to activate T cells [2]. This combination of PMA and ionomycin activates the transcription factors NF-κB and NFAT leading to the production of the cytokines, such as IL-2 [3, 4].

       

      References:

      1. Pinton P. et al., 2008. Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene. 27(50):6407-18.
      2. R?th D. et al., 2014. Dynamin related protein 1-dependent mitochondrial fission regulates oxidative signalling in T cells. FEBS Lett. 588(9):1749-54.
      3. Wang S. et al., 2013. An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. PLoS Genet. 9(9):e1003750.
      4. Ai W. et al., 2013. Optimal method to stimulate cytokine production and its use in immunotoxicity assessment. Int J Environ Res Public Health. 10(9):3834-42.


      Specifications

      Description: NFAT activator

      CAS number: 56092-82-1

      Formula: C41H70O9 .Ca2+

      Molecular weight: 747.07

      Purity: > 97% by UHPLC

      Solubility: 10 mg/ml (13.38 mM) in DMSO

      Quality control:

      • The biological activity has been determined by assessing NFAT activation in Jurkat-Lucia™ NFAT cells.

      • The absence of endotoxins and other bacterial contaminants has been confirmed using HEK-Blue™ TLR4 and HEK-Blue™ TLR2 cells.


      Contents

      • inh-ion: 1 mg ionomycin calcium salt

      room temperature Product is shipped at room temperature

      store Stored at -20°C.


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