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    1. 產(chǎn)品中心您現(xiàn)在的位置:首頁 > 產(chǎn)品展示 > 抗體 > 內(nèi)參抗體 > InVivoMab anti-mouse CTLA-4 (CD152)

      InVivoMab anti-mouse CTLA-4 (CD152)

      更新時間:2022-01-27

      簡要描述:

      The 9D9 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28

      型號:廠商性質(zhì):代理商瀏覽量:544

      The 9D9 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily. CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses. CTLA-4 plays roles in induction and/or maintenance of immunological tolerance, thymocyte development, and regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation has been demonstrated in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a lymphoproliferative disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade.


      產(chǎn)品名稱:InVivoMab anti-mouse CTLA-4 (CD152)

      反應(yīng)種屬:mouse

      宿主來源:mouse

      實驗應(yīng)用:in vivo CTLA-4 neutralization

      同種型:IgG2b

      克隆性:Monoclonal

      克隆號:9D9

      產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml

      保存溫度:Undiluted at 4°C in the dark

      運輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

      預(yù)期分子量:150 kDa

      產(chǎn)品形式:液體

      有效期:One year from the date of receipt if stored as recommended

      產(chǎn)地:美國


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