1. Donanemab biosimilar is a humanized IgG1κ antibody against human amyloid-β protein precursor (APP).
2. Specifically reacts with abeta 42 (Aβ42) that drives the pathogenesis of Alzheimer’s disease (AD).
3. Donanemab biosimilars impede the progression of AD by clearing plaques through microglialmediated phagocytosis in mice without causing microhemorrhages.
4. Studies involving Alzheimer's disease and Down syndrome experimental models use the donanemab biosimilar