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    1. 技術(shù)文章您現(xiàn)在的位置:首頁 > 技術(shù)文章 > BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

      更新時(shí)間:2024-02-19   點(diǎn)擊次數(shù):422次

      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

       

      產(chǎn)品描述:

      FGK4.5-CP133單克隆抗體是原始FGK4.5單克隆抗體的重組嵌合型抗體??勺兘Y(jié)構(gòu)域序列與原始FGK4.5克隆號(hào)相同,但是恒定區(qū)序列已經(jīng)從大鼠IgG2a變?yōu)樾∈驣gG2a。FGK4.5-CP133抗體像原始大鼠IgG2a抗體一樣,不包含F(xiàn)c突變。

       

      FGK4.5-CP133單克隆抗體能與小鼠CD40(也稱為Bp50)反應(yīng)。CD40是一種48 kDa的I型跨膜糖蛋白,屬于腫瘤壞死因子受體(TNFR)超家族。CD40廣泛表達(dá)于抗原呈遞細(xì)胞(APCs),如樹突狀細(xì)胞、B細(xì)胞、巨噬細(xì)胞和單核細(xì)胞,以及非免疫內(nèi)皮細(xì)胞、基底上皮細(xì)胞和一系列腫瘤細(xì)胞上。CD40與其配體CD154結(jié)合后,作為共刺激分子激活B細(xì)胞、樹突狀細(xì)胞、單核細(xì)胞和其他APCs。CD40在B細(xì)胞活化、分化、增殖和免疫球蛋白同種型轉(zhuǎn)換以及樹突狀細(xì)胞成熟中起作用。激動(dòng)性CD40單克隆抗體已被證明能激活A(yù)PCs并促進(jìn)抗腫瘤T細(xì)胞反應(yīng)。FGK4.5單克隆抗體是一種激動(dòng)性抗體,已被證明能激活表達(dá)CD40的APC。FGK4.5單克隆抗體也可用于體外和體內(nèi)抑制CD40/CD154相互作用。

      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40


      產(chǎn)品詳情:

      產(chǎn)品名稱

      RecombiMAb anti-mouse CD40/欣博盛生物

      產(chǎn)品貨號(hào)

      CP133

      產(chǎn)品規(guī)格

      1/5/25/50/100mg

      反應(yīng)種屬

      Mouse

      克隆號(hào)

      FGK4.5-CP133

      同種型

      Mouse IgG2a(switched from rat IgG2a)

      免疫原

      Recombinant mouse CD40 fusion protein

      實(shí)驗(yàn)應(yīng)用

      in vivo CD40 activation*
      in vitro B cell stimulation/activation*
      *Reported for the original rat IgG2a FGK4.5 antibody

      產(chǎn)品形式

      PBS, pH 7.0,Contains no stabilizers or preservatives

      純度

      >95%, Determined by SDS-PAGE

      聚合

      <5%, Determined by SEC

      無菌處理

      0.2 µm filtration

      純化方式

      Protein G

      分子量

      150 kDa

      小鼠病原檢測(cè)

      Ectromelia/Mousepox Virus: Negative

      Hantavirus: Negative

      K Virus: Negative

      Lactate Dehydrogenase-Elevating Virus: Negative

      Lymphocytic Choriomeningitis virus: Negative

      Mouse Adenovirus: Negative

      Mouse Cytomegalovirus: Negative

      Mouse Hepatitis Virus: Negative

      Mouse Minute Virus: Negative

      Mouse Norovirus: Negative

      Mouse Parvovirus: Negative

      Mouse Rotavirus: Negative

      Mycoplasma Pulmonis: Negative

      Pneumonia Virus of Mice: Negative

      Polyoma Virus: Negative

      Reovirus Screen: Negative

      Sendai Virus: Negative

      Theiler’s Murine Encephalomyelitis: Negative

      保存條件

      抗體原液保存在4°C,不能冷凍保存。

      推薦同型對(duì)照

      InVivoPlus mouse IgG2a isotype control, unknown specificity(貨號(hào)BP0085)

      推薦抗體稀釋液

      InVivoPure pH 7.0 Dilution Buffer(貨號(hào)IP0070)

       

       該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻(xiàn)引用:

      應(yīng)用

      文章

      體內(nèi)CD40激活

      (in vivo CD40 activation)

      1. Bauche, D., et al. (2018). 'LAG3(+) Regulatory T Cells Restrain Interleukin-23-

      Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid 

      Cell-Driven Colitis' Immunity 49(2): 342-352 e345.

      2. Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce 

      antitumour T-cell immunity' Nature 521(7550): 99-104.

      3. Conde, P., et al. (2015). 'DC-SIGN(+) Macrophages Control the Induction of 

      Transplantation Tolerance' Immunity 42(6): 1143-1158.

      4. Bartkowiak, T., et al. (2015). 'Unique potential of 4-1BB agonist antibody to promote 

      durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine' Proc 

      Natl Acad Sci U S A 112(38): E5290-5299.

      體外B細(xì)胞刺激/激活

      (in vitro B cell stimulation/activation)

      1. Xu, H., et al. (2015). 'Regulation of bifurcating B cell trajectories by mutual antagonism 

      between transcription factors IRF4 and IRF8' Nat Immunol .

      2. Muppidi, J. R., et al. (2014). 'Loss of signalling via Galpha13 in germinal centre 

      B-cell-derived lymphoma' Nature 516(7530): 254-258.   

       


       

      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CD40

      更多產(chǎn)品詳情請(qǐng)聯(lián)系 BioXCell 中國(guó)授權(quán)代理——欣博盛生物