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      技術(shù)文章您現(xiàn)在的位置：首頁 > 技術(shù)文章 > BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)
       
      
      
        
      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)
      
        
      更新時(shí)間：2024-01-23      點(diǎn)擊次數(shù)：479次
      
        
      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)
       
      產(chǎn)品描述：
      9D9-CP008單克隆抗體是原始9D9單克隆抗體的重組嵌合型抗體。可變結(jié)構(gòu)域序列與原始9D9克隆號相同，但是恒定區(qū)序列已經(jīng)從小鼠IgG2b變?yōu)樾∈驣gG2a。9D9-CP008單克隆抗體在Fc片段中也含有LALA-PG突變，使其無法與內(nèi)源性Fcγ受體結(jié)合。
       
      9D9-CP008單克隆抗體能與小鼠CTLA-4(細(xì)胞毒性T淋巴細(xì)胞抗原-4)反應(yīng)，CTLA-4也稱為CD152。CTLA-4是一種33 kDa的細(xì)胞表面受體，由屬于免疫球蛋白超家族CD28家族的Ctla4基因編碼。CTLA-4在活化的T淋巴細(xì)胞和B淋巴細(xì)胞上表達(dá)。CTLA-4在結(jié)構(gòu)上類似于T細(xì)胞共刺激蛋白CD28，兩種分子都與B7家族成員B7-1 (CD80)和B7-2 (CD86)結(jié)合。在與配體結(jié)合時(shí)，CTLA-4負(fù)調(diào)節(jié)細(xì)胞介導(dǎo)的免疫反應(yīng)。CTLA-4在誘導(dǎo)和/或維持免疫耐受、胸腺細(xì)胞發(fā)育和保護(hù)性免疫調(diào)節(jié)中起作用。CTLA-4在免疫下調(diào)中的關(guān)鍵作用已經(jīng)在CTLA-4缺陷小鼠中得到證實(shí)，這些小鼠在3-5周齡時(shí)由于淋巴增生性疾病的發(fā)展而死亡。CTLA-4目前是腫瘤免疫治療中的熱門免疫檢查點(diǎn)靶點(diǎn)之一。
       
      產(chǎn)品詳情：
      產(chǎn)品名稱
      RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)/欣博盛生物
      產(chǎn)品貨號
      CP008
      產(chǎn)品規(guī)格
      1mg
      反應(yīng)種屬
      Mouse
      克隆號
      9D9-CP008
      同種型
      Mouse IgG2b(switched from mouse IgG2a)
      免疫原
      Not available or unknown
      實(shí)驗(yàn)應(yīng)用
      in vivo CTLA-4 neutralization*
      Western blot*
      *Reported for the original mouse IgG2b 9D9 antibody
      產(chǎn)品形式
      PBS, pH 7.0,Contains no stabilizers or preservatives
      純度
      >95%, Determined by SDS-PAGE
      聚合
      <5%, Determined by SEC
      無菌處理
      0.2 µm filtration
      純化方式
      Protein A
      分子量
      150 kDa
      小鼠病原檢測
      Ectromelia/Mousepox Virus: Negative
      Hantavirus: Negative
      K Virus: Negative
      Lactate Dehydrogenase-Elevating Virus: Negative
      Lymphocytic Choriomeningitis virus: Negative
      Mouse Adenovirus: Negative
      Mouse Cytomegalovirus: Negative
      Mouse Hepatitis Virus: Negative
      Mouse Minute Virus: Negative
      Mouse Norovirus: Negative
      Mouse Parvovirus: Negative
      Mouse Rotavirus: Negative
      Mycoplasma Pulmonis: Negative
      Pneumonia Virus of Mice: Negative
      Polyoma Virus: Negative
      Reovirus Screen: Negative
      Sendai Virus: Negative
      Theiler’s Murine Encephalomyelitis: Negative
      保存條件
      抗體原液保存在4°C，不能冷凍保存。
      推薦抗體稀釋液
      InVivoPure pH 7.0 Dilution Buffer（貨號IP0070）
       
      該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻(xiàn)引用：
      應(yīng)用
      文章
      體內(nèi)CTLA-4中和
      (in vivo CTLA-4 
      neutralization)
      1. Dai, M., et al. (2015). 'Curing mice with large tumors by locally 
      delivering combinations of immunomodulatory antibodies' 
      Clin Cancer Res 21(5): 1127-1138.
      2. Zippelius, A., et al. (2015). 'Induced PD-L1 expression mediates 
      acquired resistance to agonistic anti-CD40 treatment' Cancer Immunol 
      Res 3(3): 236-244.
      3. Redmond, W. L., et al. (2014). 'Combined targeting of costimulatory 
      (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T 
      cells capable of driving robust antitumor immunity' Cancer Immunol 
      Res 2(2): 142-153.
      4. Condamine, T., et al. (2014). 'ER stress regulates myeloid-derived 
      suppressor cell fate through TRAIL-R-mediated apoptosis' J Clin Invest 
      124(6): 2626-2639.
      5. Muller, P., et al. (2014). 'Microtubule-depolymerizing agents used in 
      antibody-drug conjugates induce antitumor immunity by stimulation of 
      dendritic cells' Cancer Immunol Res 2(8): 741-755.
      6. Bulliard, Y., et al. (2013). 'Activating Fc gamma receptors contribute 
      to the antitumor activities of immunoregulatory receptor-targeting 
      antibodies' J Exp Med 210(9): 1685-1693.
       
       
       
      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)
      更多產(chǎn)品詳情請聯(lián)系 BioXCell 中國授權(quán)代理——欣博盛生物