AbD Serotec公司(現(xiàn)已被伯樂Bio-Rad收購)是全/球/領(lǐng)/先的巨噬細胞標志物抗體供應(yīng)商,其生產(chǎn)的MCA497, Rat Anti Mouse F4/80 Clone CI:A3-1是著名的成熟小鼠巨噬細胞表面特異性標志物抗體,有將近400篇的文獻引用,提供多達30種的包裝形式,可用于FC、WB,IF、IHC等7種應(yīng)用。AbD Serotec享有該克隆的專/利,是該抗體唯/一/的商業(yè)化生產(chǎn)商。 MCA1957識別小鼠細胞表面macrosialin,為人CD68的同源物,是專門表達于組織巨噬細胞的一種重度糖基化的跨膜糖蛋白。
AbD Serotec公司 F4/80 產(chǎn)品參考文獻 1. Austyn, J.M. and Gordon, S. (1981) F4/80 , a monoclonal antibody directed specifically against the mouse macrophage.Eur. J. Immunol. 11: 805-815. 2. Hume, D.A., Perry, V.H., and Gordon, S. (1984) The Mononuclear Phagocyte System of the Mouse defined by Immunohistochemical Localisation of Antigen F4/80: Macrophages Associated with Epithelia.The Anatomical Record 210: 503-512. 3. Lee, S.H. et al. (1985) Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80.J. Exp. Med. 161: 475-489. 4. Gordon, S. et al. (1992) Antigen markers of macrophage differentiation in murine tissues. Curr. Top. Micro. Immunol. 181: 1-37. 5. Uaesoontrachoon, K. et al. (2013) Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury.Dis Model Mech. 6: 197-205.